Package org.biojava.bio.program.das

Class DASSequence

  • All Implemented Interfaces:
    Annotatable, FeatureHolder, RealizingFeatureHolder, Sequence, SymbolList, Changeable
    public class DASSequence
extends AbstractChangeable
    Sequence reflecting a DAS reference sequence, possibly decorated with one of more annotation sets.

    This is an first-pass implementation. In future, I hope to add query optimization for better performance on large sequences, and pluggable transducers to parameterize the creation of BioJava features.

    Since:
    1.1
    Author:
    Thomas Down, Matthew Pocock, David Huen

    • Field Detail

      • ANNOTATIONS

        public static final ChangeType ANNOTATIONS
        Change type which indicates that the set of annotation servers used by this DASSequence has been changed. This extends Feature.FEATURES as the addition and removal of annotation servers adds and removes features.

      • PROPERTY_ANNOTATIONSERVER

        public static final java.lang.String PROPERTY_ANNOTATIONSERVER
        See Also:
        Constant Field Values

      • PROPERTY_FEATUREID

        public static final java.lang.String PROPERTY_FEATUREID
        See Also:
        Constant Field Values

      • PROPERTY_FEATURELABEL

        public static final java.lang.String PROPERTY_FEATURELABEL
        See Also:
        Constant Field Values

      • PROPERTY_SEQUENCEVERSION

        public static final java.lang.String PROPERTY_SEQUENCEVERSION
        See Also:
        Constant Field Values

      • annotationForwarder

        protected transient ChangeForwarder annotationForwarder

    • Method Detail

      • dataSourceURLs

        public java.util.Set dataSourceURLs()

      • getChangeSupport

        protected ChangeSupport getChangeSupport​(ChangeType ct)
        Description copied from class: AbstractChangeable
        Called to retrieve the ChangeSupport for this object.

        Your implementation of this method should have the following structure: 

         ChangeSupport cs = super.getChangeSupport(ct);

 if(someForwarder == null && ct.isMatching(SomeInterface.SomeChangeType)) {
   someForwarder = new ChangeForwarder(...

   this.stateVariable.addChangeListener(someForwarder, VariableInterface.AChange);
 }

 return cs;
        It is usual for the forwarding listeners (someForwarder in this example) to be transient and lazily instantiated. Be sure to register & unregister the forwarder in the code that does the ChangeEvent handling in setter methods.
        Overrides:
        getChangeSupport in class AbstractChangeable

      • getAlphabet

        public Alphabet getAlphabet()
        Description copied from interface: SymbolList
        The alphabet that this SymbolList is over.

        Every symbol within this SymbolList is a member of this alphabet. alphabet.contains(symbol) == true for each symbol that is within this sequence.

        Specified by:
        getAlphabet in interface SymbolList
        Returns:
        the alphabet

      • iterator

        public java.util.Iterator iterator()
        Description copied from interface: SymbolList
        An Iterator over all Symbols in this SymbolList.

        This is an ordered iterator over the Symbols. It cannot be used to edit the underlying symbols.

        Specified by:
        iterator in interface SymbolList
        Returns:
        an iterator

      • length

        public int length()
        Description copied from interface: SymbolList
        The number of symbols in this SymbolList.
        Specified by:
        length in interface SymbolList
        Returns:
        the length

      • seqString

        public java.lang.String seqString()
        Description copied from interface: SymbolList
        Stringify this symbol list.

        It is expected that this will use the symbol's token to render each symbol. It should be parsable back into a SymbolList using the default token parser for this alphabet.

        Specified by:
        seqString in interface SymbolList
        Returns:
        a string representation of the symbol list

      • subStr

        public java.lang.String subStr​(int start,
                               int end)
        Description copied from interface: SymbolList
        Return a region of this symbol list as a String.

        This should use the same rules as seqString.

        Specified by:
        subStr in interface SymbolList
        Parameters:
        start - the first symbol to include
        end - the last symbol to include
        Returns:
        the string representation

      • subList

        public SymbolList subList​(int start,
                          int end)
        Description copied from interface: SymbolList
        Return a new SymbolList for the symbols start to end inclusive.

        The resulting SymbolList will count from 1 to (end-start + 1) inclusive, and refer to the symbols start to end of the original sequence.

        Specified by:
        subList in interface SymbolList
        Parameters:
        start - the first symbol of the new SymbolList
        end - the last symbol (inclusive) of the new SymbolList

      • symbolAt

        public Symbol symbolAt​(int pos)
        Description copied from interface: SymbolList
        Return the symbol at index, counting from 1.
        Specified by:
        symbolAt in interface SymbolList
        Parameters:
        pos - the offset into this SymbolList
        Returns:
        the Symbol at that index

      • toList

        public java.util.List toList()
        Description copied from interface: SymbolList
        Returns a List of symbols.

        This is an immutable list of symbols. Do not edit it.

        Specified by:
        toList in interface SymbolList
        Returns:
        a List of Symbols

      • edit

        public void edit​(Edit e)
          throws ChangeVetoException
        Description copied from interface: SymbolList
        Apply an edit to the SymbolList as specified by the edit object.

        Description

        All edits can be broken down into a series of operations that change contiguous blocks of the sequence. This represent a one of those operations.

        When applied, this Edit will replace 'length' number of symbols starting a position 'pos' by the SymbolList 'replacement'. This allow to do insertions (length=0), deletions (replacement=SymbolList.EMPTY_LIST) and replacements (length>=1 and replacement.length()>=1).

        The pos and pos+length should always be valid positions on the SymbolList to:

        • be edited (between 0 and symL.length()+1).
        • To append to a sequence, pos=symL.length()+1, pos=0.
        • To insert something at the beginning of the sequence, set pos=1 and length=0.

        Examples

         SymbolList seq = DNATools.createDNA("atcaaaaacgctagc");
 System.out.println(seq.seqString());

 // delete 5 bases from position 4
 Edit ed = new Edit(4, 5, SymbolList.EMPTY_LIST);
 seq.edit(ed);
 System.out.println(seq.seqString());

 // delete one base from the start
 ed = new Edit(1, 1, SymbolList.EMPTY_LIST);
 seq.edit(ed);

 // delete one base from the end
 ed = new Edit(seq.length(), 1, SymbolList.EMPTY_LIST);
 seq.edit(ed);
 System.out.println(seq.seqString());

 // overwrite 2 bases from position 3 with "tt"
 ed = new Edit(3, 2, DNATools.createDNA("tt"));
 seq.edit(ed);
 System.out.println(seq.seqString());

 // add 6 bases to the start
 ed = new Edit(1, 0, DNATools.createDNA("aattgg");
 seq.edit(ed);
 System.out.println(seq.seqString());

 // add 4 bases to the end
 ed = new Edit(seq.length() + 1, 0, DNATools.createDNA("tttt"));
 seq.edit(ed);
 System.out.println(seq.seqString());

 // full edit
 ed = new Edit(3, 2, DNATools.createDNA("aatagaa");
 seq.edit(ed);
 System.out.println(seq.seqString());
        Specified by:
        edit in interface SymbolList
        Parameters:
        e - the Edit to perform
        Throws:
        ChangeVetoException - if either the SymboList does not support the edit, or if the change was vetoed

      • getName

        public java.lang.String getName()
        Description copied from interface: Sequence
        The name of this sequence.

        The name may contain spaces or odd characters.

        Specified by:
        getName in interface Sequence
        Returns:
        the name as a String

      • getURN

        public java.lang.String getURN()
        Description copied from interface: Sequence
        A Uniform Resource Identifier (URI) which identifies the sequence represented by this object. For sequences in well-known database, this may be a URN, e.g. 
         urn:sequence/embl:AL121903
        It may also be a URL identifying a specific resource, either locally or over the network 
         file:///home/thomas/myseq.fa|seq22
 http://www.mysequences.net/chr22.seq
        Specified by:
        getURN in interface Sequence
        Returns:
        the URI as a String

      • features

        public java.util.Iterator features()
        Description copied from interface: FeatureHolder
        Iterate over the features in no well defined order.
        Specified by:
        features in interface FeatureHolder
        Returns:
        an Iterator

      • containsFeature

        public boolean containsFeature​(Feature f)
        Description copied from interface: FeatureHolder
        Check if the feature is present in this holder.
        Specified by:
        containsFeature in interface FeatureHolder
        Parameters:
        f - the Feature to check
        Returns:
        true if f is in this set

      • filter

        public FeatureHolder filter​(FeatureFilter ff)
        Description copied from interface: FeatureHolder
        Query this set of features using a supplied FeatureFilter.
        Specified by:
        filter in interface FeatureHolder
        Parameters:
        ff - the FeatureFilter to apply.
        Returns:
        all features in this container which match filter.

      • filter

        public FeatureHolder filter​(FeatureFilter ff,
                            boolean recurse)
        Description copied from interface: FeatureHolder
        Return a new FeatureHolder that contains all of the children of this one that passed the filter fc. This method is scheduled for deprecation. Use the 1-arg filter instead.
        Specified by:
        filter in interface FeatureHolder
        Parameters:
        ff - the FeatureFilter to apply
        recurse - true if all features-of-features should be scanned, and a single flat collection of features returned, or false if just immediate children should be filtered.

      • getSchema

        public FeatureFilter getSchema()
        Description copied from interface: FeatureHolder
        Return a schema-filter for this FeatureHolder. This is a filter which all Features immediately contained by this FeatureHolder will match. It need not directly match their child features, but it can (and should!) provide information about them using FeatureFilter.OnlyChildren filters. In cases where there is no feature hierarchy, this can be indicated by including FeatureFilter.leaf in the schema filter.

        For the truly non-informative case, it is possible to return FeatureFilter.all. However, it is almost always possible to provide slightly more information that this. For example, Sequence objects should, at a minimum, return FeatureFilter.top_level. Feature objects should, as a minimum, return FeatureFilter.ByParent(new FeatureFilter.ByFeature(this)).

        Specified by:
        getSchema in interface FeatureHolder
        Returns:
        the schema filter

      • countFeatures

        public int countFeatures()
        Description copied from interface: FeatureHolder
        Count how many features are contained.
        Specified by:
        countFeatures in interface FeatureHolder
        Returns:
        a positive integer or zero, equal to the number of features contained

      • getAnnotation

        public Annotation getAnnotation()
        Description copied from interface: Annotatable
        Should return the associated annotation object.
        Specified by:
        getAnnotation in interface Annotatable
        Returns:
        an Annotation object, never null